During a press conference at the State Capitol, Governor Mike Parson announced an end to the COVID-19 crisis in Missouri and that the state will be shifting to an endemic phase of the pandemic on Friday, April 1, 2022. A whole-of-government COVID-19 emergency response was taken for more than two years, an effort that responded to the needs of all Missourians during the global pandemic and sustained state operations as more was learned about the novel virus. Vaccines, testing resources, and treatments are now readily available for all Missourians, and much of the population now has some immunity to the virus. “Over the past two years, we have learned a lot that will help us respond to future outbreaks and challenges that may come our way,” Governor Parson said. “We don’t know if this virus will ever completely go away, but we do know that there is no longer a need to live in crisis mode and that we can shift our response to meet the current needs of Missourians. The COVID-19 crisis is over in the state of Missouri, and we are moving on.” The SARS-CoV-2 virus, which causes COVID-19, is expected to continue to circulate in communities, meaning it will be considered endemic like many other diseases. The endemicity also means that surveillance priority will change from monitoring case numbers to monitoring disease severity and societal impact as new waves of infection come and go. This transition does not minimize the continued importance of public health surveillance, investigation, and response activities, as is necessary to mitigate any disease.